Primera part del quadre
| Rafa NADAL (ESP) - 1 | |||
| BYE | |||
| Marius COPIL (ROU) | 3 | 7 | 5 |
| Leonardo MAYER (ARG) | 6 | 6 | 7 |
| David FERRER (ESP) | 6 | 6 | 7 |
| Mischa ZVEREV (GER) | 3 | 7 | 5 |
| BYE | |||
| Lucas POUILLE (FRA) - 15 | |||
| David GOFFIN (BEL) - 10 | |||
| BYE | |||
| Hugo DELLIEN (BEL) | 3 | 1 | |
| Jan-Lennard STRUFF (GER) | 6 | 6 | |
| Marton FUCSOVICS (HUN) | 6 | 6 | |
| Denis KUDLA (USA) | 4 | 1 | |
| BYE | |||
| Stefanos TSITSIPAS (GRE) - 5 | |||
| Dominic THIEM (AUT) - 3 | |||
| BYE | |||
| Yoshihito NISHIOKA (JPN) | 6 | 4 | 2 |
| Diego SCHWARTZMAN (ARG) | 4 | 6 | 6 |
| Pedro SOUSA (POR) | 6 | 4 | 0 |
| Jaume MUNAR (ESP) | 2 | 6 | 6 |
| BYE | |||
| Frances TIAFOE (USA) - 14 | |||
| Pablo CARREÑO (ESP) - 12 | |||
| BYE | |||
| Juan Ignacio LONDERO (ARG) | 5 | 2 | |
| Benoit PAIRE (FRA) | 7 | 6 | |
| Guido PELLA (ARG) | 3 | 7 | 6 |
| Joao SOUSA (POR) | 6 | 6 | 2 |
| BYE | |||
| Karen KHACHANOV (RUS) - 6 |
Segona part del quadre
| Roberto CARBALLÉS (ESP) | |||
| BYE | |||
| Nocola KUHN (ESP) | 7 | 4 | 6 |
| Federico DELBONIS (ARG) | 6 | 6 | 2 |
| Martin KLIZAN (SVK) | 5 | 4 | |
| Cristian GARÍN (CHI) | 7 | 6 | |
| BYE | |||
| Denis SHAPOVALOV (CAN) - 9 | |||
| Félix AUGER-ALIASSIME (CAN) - 16 | |||
| BYE | |||
| Malek JAZIRI (TUN) | 6 | 6 | 6 |
| Guido ANDREOZZI (ARG) | 7 | 4 | 2 |
| Taylor FRITZ (USA) | 6 | 6 | |
| Reilly OPELKA (USA) | 3 | 4 | |
| BYE | |||
| Kei NISHIKORI (JPN) - 4 | |||
| Daniil MEDVEDEV (RUS) - 7 | |||
| BYE | |||
| Albert RAMOS (ESP) | 6 | 6 | |
| Cameron NORRIE (GBR) | 2 | 2 | |
| Mackenzie MCDONALD (USA) | 6 | 6 | |
| Taro DANIEL (JPN) | 2 | 2 | |
| BYE | |||
| Gilles SIMON (FRA) - 11 | |||
| Grigor DIMITROV (BUL) - 13 | |||
| BYE | |||
| Feliciano LÓPEZ (ESP) | 4 | 3 | |
| Fernando VERDASCO (ESP) | 6 | 6 | |
| Nicolás JARRY (CHI) | 7 | 4 | 6 |
| Marcel GRANOLLERS (ESP) | 5 | 6 | 4 |
| BYE | |||
| Alexander ZVEREV (GER) - 2 |